If we are filled with ignorance and foolishness,  immediate and future happiness will elude us. Why? Because afflictive emotions have their origins in ignorance; from afflictive emotions, negative karma emerges; and negative karma is the cause of all suffering. This means that ignorance is only the source of afflictive emotions and sufferings, and it is the root of all faults.

-- His Holiness Jigme Phuntsok Rinpoche